{"id":8010,"date":"2025-02-06T22:29:04","date_gmt":"2025-02-06T22:29:04","guid":{"rendered":"https:\/\/legendhorizon.com\/?p=8010"},"modified":"2025-02-06T22:29:05","modified_gmt":"2025-02-06T22:29:05","slug":"scientists-find-a-kill-switch-in-the-body-that-can-destroy-cancer-cells","status":"publish","type":"post","link":"https:\/\/legendhorizon.com\/scientists-find-a-kill-switch-in-the-body-that-can-destroy-cancer-cells\/","title":{"rendered":"Scientists find a \u2018kill switch\u2019 in the body that can destroy cancer cells"},"content":{"rendered":"\n<p>In the fight against&nbsp;<a href="%5C%22https:%5C/%5C/boreddaddy.com%5C/how-your-bowel-movements-reveal-clues-about-colon-cancer%5C/%5C%22">cancer, every breakthrough brings hope to millions people affected by this devastating disease.\n\n\n\n<p>Now, the scientists at the UC Davis Comprehensive Cancer Center in&nbsp;Sacramento, California presented a new promising route to treatment of cancer. Namely, they detailed the results of their study in a publication of the&nbsp;<em><a href="%5C%22https:%5C/%5C/www.nature.com%5C/articles%5C/s41418-023-01229-7%5C%22">Cell Death &amp; Differentiation&nbsp;journal.\n\n\n\n<h2 class='\"wp-block-heading\"'>The findings show that CD95 receptors, known as Fas, or \u201cdeath receptors,\u201d send a signal that causes cancer cells to \u201cself-destruct.\u201d\n\n\n\n</h2><p>\u201cPrevious efforts to target this receptor have been unsuccessful. But now that we\u2019ve identified this epitope (target), there could be a therapeutic path forward to target Fas in tumors,\u201d Jogender Tushir-Singh, a senior author of the study and associate professor in the Department of Medical Microbiology and Immunology,&nbsp;<a href="%5C%22https:%5C/%5C/www.foxnews.com%5C/health%5C/potential-cancer-breakthrough-newly-found-kill-switch-triggers-death-cancer-cells-one-two-punch%5C%22">stated&nbsp;in the release.<img decoding='\"async\"' src="%5C%22https:%5C/%5C/go.ezodn.com%5C/utilcave_com%5C/ezoicbwa.png%5C%22" alt='\"Ezoic\"' class='\"\"'>\n\n\n\n<figure class='\"wp-block-image\"'><img decoding='\"async\"' src="%5C%22https:%5C/%5C/boreddaddy.com%5C/wp-content%5C/uploads%5C/2025%5C/02%5C/pexels-photo-5910774-1024x683.webp?ezimgfmt=rs:470x313%5C/rscb2%5C/ng:webp%5C/ngcb2%5C%22" alt='\"\"' class='\"wp-image-71441\"\/'><figcaption class='\"wp-element-caption\"'><a href="%5C%22https:%5C/%5C/www.pexels.com%5C/photo%5C/cancer-word-spelled-on-scrabble-tiles-5910774%5C/%5C%22">Pexels\n\n\n\n<p>These CD95 receptors are located on the cell surface. Upon activation, they trigger a series of molecular processes that result in cell destruction. They play a crucial role in maintaining a cellular balance but scientists hadn\u2019t explored their full potential until recently.\n\n\n\n</p><p>One of the biggest challenges in the fight against cancer is the therapeutic resistance, meaning the cells develop resistance to conventional treatments.<img decoding='\"async\"' src="%5C%22https:%5C/%5C/go.ezodn.com%5C/utilcave_com%5C/ezoicbwa.png%5C%22" alt='\"Ezoic\"' class='\"\"'>\n\n\n\n</p><h2 class='\"wp-block-heading\"'>At the time being, the conventional treatments include surgery, chemotherapy, and radiotherapy.\n\n\n\n</h2><p>Additionally, immune-based therapies have been also used in the fight against this disease, such as CAR (chimeric antigen receptor) T-cell therapy, but their effectiveness is limited to only certain types of cancer.\n\n\n\n</p><p>\u201cDespite being decently successful in&nbsp;liquid tumors, such as leukemia spectrum cancers, long-term remission remains the biggest challenge for CAR T-cell therapies,\u201d Tushir-Singh shared with&nbsp;<em><a href="%5C%22https:%5C/%5C/www.foxnews.com%5C/health%5C/potential-cancer-breakthrough-newly-found-kill-switch-triggers-death-cancer-cells-one-two-punch%5C%22">Fox News.<img decoding='\"async\"' src="%5C%22https:%5C/%5C/go.ezodn.com%5C/utilcave_com%5C/ezoicbwa.png%5C%22" alt='\"Ezoic\"' class='\"\"'>\n\n\n\n<figure class='\"wp-block-image\"'><img decoding='\"async\"' src="%5C%22https:%5C/%5C/boreddaddy.com%5C/wp-content%5C/uploads%5C/2025%5C/02%5C/iStock-1553819635.webp?ezimgfmt=rs:470x264%5C/rscb2%5C/ng:webp%5C/ngcb2%5C%22" alt='\"\"' class='\"wp-image-71442\"\/'><figcaption class='\"wp-element-caption\"'>iStock\n\n\n\n<p>The study revealed that there are now hopes \u201cand potential solution to transform the meager success of CAR-T therapies into potentially successful [therapies for] solid tumors,\u201d not only in treating leukemia.\n\n\n\n</p><p>The discovery of the Fas epitope could eliminate cell evasion by triggering programmed cell death. So, targeting Fas in cancer therapy will not only help overcome therapeutic resistance, but also show potential for enhancing the effectiveness of current immunotherapies.\n\n\n\n</p><p>\u201cIt is evident that the success of CAR-T therapy relies on off-target killing by Fas,\u201d Tushir-Singh&nbsp;told&nbsp;<em><a href="%5C%22https:%5C/%5C/www.foxnews.com%5C/health%5C/potential-cancer-breakthrough-newly-found-kill-switch-triggers-death-cancer-cells-one-two-punch%5C%22">Fox News Digital.&nbsp;<img decoding='\"async\"' src="%5C%22https:%5C/%5C/go.ezodn.com%5C/utilcave_com%5C/ezoicbwa.png%5C%22" alt='\"Ezoic\"' class='\"\"'>\n\n\n\n<p>Further, he added: \u201cWith the current information, we researchers and doctors should screen&nbsp;potential cancer patients&nbsp;\u2014 who would be undergoing CAR-T therapy \u2014 to check for the comprehensive presence of Fas on their tumors.\u201d\n\n\n\n</p><p>Please SHARE this article with your family and friends on Facebook.\n\n\n\n</p><p>Love and Peace\n","protected":false},"excerpt":{"rendered":"</p><div class='\"mh-excerpt\"'><p>In the fight against&nbsp;cancer, every breakthrough brings hope to millions people affected by this devastating disease. Now, the scientists at the UC Davis Comprehensive Cancer <a class='\"mh-excerpt-more\"' href="%5C%22https:%5C/%5C/legendhorizon.com%5C/scientists-find-a-kill-switch-in-the-body-that-can-destroy-cancer-cells%5C/%5C%22" title='\"Scientists' find a switch in the body that can destroy cancer cells>[&hellip;]\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/legendhorizon.com\/wp-json\/wp\/v2\/posts\/8010"}],"collection":[{"href":"https:\/\/legendhorizon.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/legendhorizon.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/legendhorizon.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/legendhorizon.com\/wp-json\/wp\/v2\/comments?post=8010"}],"version-history":[{"count":1,"href":"https:\/\/legendhorizon.com\/wp-json\/wp\/v2\/posts\/8010\/revisions"}],"predecessor-version":[{"id":8011,"href":"https:\/\/legendhorizon.com\/wp-json\/wp\/v2\/posts\/8010\/revisions\/8011"}],"wp:attachment":[{"href":"https:\/\/legendhorizon.com\/wp-json\/wp\/v2\/media?parent=8010"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/legendhorizon.com\/wp-json\/wp\/v2\/categories?post=8010"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/legendhorizon.com\/wp-json\/wp\/v2\/tags?post=8010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}</a></p></div></a></em></p></figcaption></figure></a></em></p></a></figcaption></figure></a></p></a></em></p></a></p>